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Chỉ định và Liều dùng
Oral
Fever, Mild to moderate pain Adult: Available preparation
Each effervescent tab contains aspirin 400 mg and ascorbic acid 240 mg. 1-2 tabs, may repeat 4-8 hourly, if necessary. Max: 3-6 tabs daily. |
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Chống chỉ định
Gastric or duodenal ulcers. Haemophilia, thrombocytopenia or other bleeding tendencies; patients receiving anti-coagulant treatment. Hypersensitivity to aspirin or other salicylates or ascorbic acid. Severe renal impairment.
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Thận trọng
Risk of Reye's syndrome in children with varicella infection or influenza-like illnesses. Not to be used for >10 days without medical advice. Treatment should be withdrawn 1 wk prior to surgery to prevent or reduce risk of bleeding complications. Caution when used in patients with impaired renal function, severe hepatic impairment, history of GI disorders e.g. peptic ulcers, ulcerative colitis and Crohn's disease, dyspepsia and when the patient is dehydrated. Pregnancy and lactation.
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Tác dụng không mong muốn
Dizziness, GI irritation e.g. dyspepsia, nausea, vomiting, erosion, ulceration, haematemesis and melaena. Prolonged use of high doses of aspirin may cause anaemia, blood dyscrasia, GI haemorrhage and peptic ulceration.
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Quá liều
Overdose of aspirin can lead to dizziness, tinnitus, sweating, nausea, vomiting, altered glucose metabolism, mental confusion, hyperventilation, respiratory alkalosis, metabolic acidosis, ketosis, fluid and electrolyte losses. CNS depression may lead to coma, CV collapse and respiratory failure. Overdosage of vitamin C may lead to diarrhoea and GI disturbances. Treatment includes gastric lavage, forced alkaline diuresis, restoration of fluid, electrolyte and acid balance, dialysis and supportive therapy may be needed.
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Tương tác
Aspirin may increase hypoprothrombinemic effect of warfarin and other oral anticoagulants, thus increasing the risk of bleeding complications. May antagonise uricosuric effect of probenecid, phenylbutazone or sulfinpyrazone. Concurrent admin with corticosteroids may reduce the serum levels of aspirin. Aspirin may increase serum levels of methotrexate. Concurrent admin with alcohol increases risk and severity of GI bleeding and ulceration. Aspirin may reduce the absorption of vitamin C.
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Ảnh hưởng đến kết quả xét nghiệm
May falsely elevate results for blood creatinine, urate (low dose aspirin) and urea and falsely decrease results for blood thyroxine, urate and urinary 5-hydroxyindoleacetic acid (with nitrosonapthol method). Urinary vanillylmandelic acid (or 4-hydroxy-3-methoxymandelic acid) levels may be falsely increased or decreased depending on the method of analysis.
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Tác dụng
Description:
Mechanism of Action: Aspirin has pain-relieving, anti-pyretic and anti-inflammatory actions. Vitamin C is a water-soluble vitamin that is used with aspirin for the relief of pain and/or fever associated with colds and flu. Pharmacokinetics: Absorption: Vitamin C: Readily absorbed via oral admin. Metabolism: Vitamin C: Hepatic via oxidation and sulfation. |
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Bảo quản
Store below 25°C.
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Phân loại MIMS
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Đăng xuất
